All Phenotypes Hspa12a<tm1.1Zdi> MGI Mouse

abnormal macrophage morphology ( J:302786 )

• reduced macrophage recruitment to liver when fed high fat diet (HFD)

• reduced M1 polarization of macrophages in liver when fed high fat diet (HFD)

increased susceptibility to endotoxin shock ( J:302787 )

• increased LPS-induced hepatocyte pyroptosis and liver damage

• lower body temperature and activity after LPS challenge

• increased LPS-induced macrophage and neutrophil recruitment to liver

N	• normal brain weight

increased susceptibility to ischemic brain injury ( J:271786 )

• significantly worse neurological score 24h after MCAO and reperfusion treatment

• significantly more severe neuronal morphological damage (shrinkage, nuclear pyknosis) in hippocampus 24h after MCAO and reperfusion treatment

• significantly more apoptotic cells in ventral and caudal peri-infarct areas 24h after middle cerebral artery occlusion (MCAO) and reperfusion treatment

• significantly slower recovery as determined by total distance moved and movement speed in open field test 20 days after MCAO and reperfusion treatment

• 80% reduction in neurogenesis in ischemic hemisphere and 70% in hippocampus 5 days after MCAO and reperfusion treatment

increased cerebral infarct size ( J:271786 )

• ~50% increase in infarct volume 24h after middle cerebral artery occlusion (MCAO) and reperfusion treatment

decreased susceptibility to diet-induced hepatic steatosis ( J:302786 )

• reduced HFD-induced steatosis

• reduced liver weight and hepatocyte size gain when fed high fat diet (HFD)

• normal liver weight, hepatocyte size and lipid amount on regular chow

abnormal macrophage morphology ( J:302786 )

• reduced macrophage recruitment to liver when fed high fat diet (HFD)

• reduced M1 polarization of macrophages in liver when fed high fat diet (HFD)

decreased susceptibility to induced morbidity/mortality ( J:302786 )

• no high fat diet (HFD)-induced liver injury as determined by lack of elevated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity when fed HFD

• reduced liver weight and hepatocyte size gain when fed high fat diet (HFD)

• normal liver weight, hepatocyte size and lipid amount on regular chow

decreased susceptibility to weight gain ( J:287930 )

• reduced body mass gain an smaller iWAT adipocytes at age 16 weeks on regular chow

• normal body length and food intake at age 16 weeks on regular chow

decreased susceptibility to diet-induced obesity ( J:287930 )

• reduced body mass gain after 14 weeks on high fat diet (HFD)

• smaller inguinal white adipose tissue (iWAT), visceral WAT (vWAT) and mesenteric WAT (mWAT) depots after 14 weeks on HFD

• smaller adipocytes in iWAT after 14 weeks on HFD

• reduced increase in serum free fatty acid, LDL-C, HDL, cholesterol and glucose levels when fed HFD

homeostasis/metabolism phenotype ( J:287930 , J:302786 )

N	• normal glucose tolerance after 16h fasting (J:287930) • normal lipid, glucose and fasting insulin levels in serum on regular chow (J:302786)