Phenotypes associated with this allele

• Allele Symbol: Lin52^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:6306929
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lin52^em1(IMPC)J/Lin52^em1(IMPC)J	C57BL/6NJ-Lin52^em1(IMPC)J/Mmjax	MGI:6480492
ht2	Lin52^em1(IMPC)J/Lin52^+	C57BL/6NJ-Lin52^em1(IMPC)J/Mmjax	MGI:7317015

Genotype
MGI:6480492

hm1

• Allelic Composition: Lin52^em1(IMPC)J/Lin52^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Lin52^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Lin52

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Lin52^em1(IMPC)J/Lin52^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but no embryos seen at E7.5. Blastocysts grown in vitro hatch from the zona pellucida and form outgrowths.

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• although blastocyst-like embryos are recovered at normal Mendelian ratios at E3.5, no homozygous embryos are recovered at E7.5; excess resorption sites suggest that embryos elicit a decidual response in vivo

• in vitro, blastocysts hatch from the zona pellucida and form outgrowths after 3 days in culture

Genotype
MGI:7317015

ht2

• Allelic Composition: Lin52^em1(IMPC)J/Lin52⁺
• Genetic Background: C57BL/6NJ-Lin52^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Lin52

hematopoietic system

increased mean corpuscular volume ( J:211773 )

♂

IMPC - JAX

homeostasis/metabolism

decreased circulating calcium level ( J:211773 )

IMPC - JAX