Phenotypes associated with this allele

• Allele Symbol: Calhm3^em1Jkf
• Allele Name: endonuclease-mediated mutation 1, J Kevin Foskett
• Allele ID: MGI:6307099
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Calhm3^em1Jkf/Calhm3^em1Jkf	C57BL/6-Calhm3^em1Jkf	MGI:6307101

Genotype
MGI:6307101

hm1

• Allelic Composition: Calhm3^em1Jkf/Calhm3^em1Jkf
• Genetic Background: C57BL/6-Calhm3^em1Jkf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

taste/olfaction

taste/olfaction phenotype ( J:269649 )

N • mice exhibit normal response to capsaicin and citric acid

abnormal gustatory system physiology ( J:269649 )

• type II taste bud cells lack voltage-activated nonselective currents

• taste bud taste-evoked ATP release is abolished

• however, taste-evoked global internal calcium ion concentration signals are normal

abnormal bitter taste sensitivity ( J:269649 )

• reduced avoidance

abnormal salty taste sensitivity ( J:269649 )

• mice exhibit reduced avoidance of CaCl2 and high concentrations of NaCl compared with wild-type mice

• however, response to low concentration of NaCl is normal

abnormal sweet taste sensitivity ( J:269649 )

• loss of preference

abnormal umami taste sensitivity ( J:269649 )

• loss of preference