Phenotypes associated with this allele

• Allele Symbol: Fndc5^tm1.1Brsp
• Allele Name: targeted mutation 1.1, Bruce M Spiegelman
• Allele ID: MGI:6307130
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fndc5^tm1.1Brsp/Fndc5^tm1.1Brsp	involves: C57BL/6J	MGI:6307746

Genotype
MGI:6307746

hm1

• Allelic Composition: Fndc5^tm1.1Brsp/Fndc5^tm1.1Brsp
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:269575 )

♂N • male mice exhibit normal bone mass

abnormal osteocyte morphology ( J:269575 )

♀ • ovariectomized mice lack osteocytic osteolysis and lacuna enlargement unlike wild-type mice

abnormal osteocyte lacuna morphology ( J:269575 )

♀ • ovariectomized mice lack osteocytic osteolysis and lacuna enlargement unlike wild-type mice

decreased susceptibility to osteoporosis ( J:269575 )

♀ • in ovariectomized mice due to reduced bone resorption

♀ • however, osteoblast number and bone formation is normal

increased trabecular bone connectivity density ( J:269575 )

increased trabecular bone mass ( J:269575 )

• however, cortical bone indices are normal

decreased bone resorption ( J:269575 )

♀ • in ovariectomized mice due to reduced bone resorption