Phenotypes associated with this allele

• Allele Symbol: Cela2a^tm1Bdr
• Allele Name: targeted mutation 1, Michael Bader
• Allele ID: MGI:6313718
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cela2a^tm1Bdr/Cela2a^tm1Bdr	involves: 129P2/OlaHsd * C57BL/6	MGI:6314214

Genotype
MGI:6314214

hm1

• Allelic Composition: Cela2a^tm1Bdr/Cela2a^tm1Bdr
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:275582 )

N • normal mean arterial pressure

N • normal systolic arterial pressure (SAP) and SAP power density

N • normal cardiac sympathetic modulation, as assessed by 0V pattern occurrence in symbolic analysis of three-beat sequences

N • normal vagus nerve cardiac modulation, as assessed by 2UV pattern occurrence in symbolic analysis of three-beat sequences

N • normal baroreflex

N • cardiac ejection fraction and fractional shortening

N • heart weight

N • interventricular septum thickness

N • cardiac index

N • cardiomyocyte size and collagen density

decreased heart left ventricle size ( J:275582 )

• smaller diameter

• smaller area

decreased heart right ventricle size ( J:275582 )

• smaller area

decreased cardiac output ( J:275582 )

decreased cardiac stroke volume ( J:275582 )

abnormal heartbeat ( J:275582 )

• reduced power for LF band higher power for HF band, resulting in lower LF/HF ratio in spectral power density of heart rate

• normal systolic arterial pressure (SAP) and SAP power density

decreased heart rate ( J:275582 )

• lower basal heart rate

• reduced heart rate under anesthesia

nervous system

nervous system phenotype ( J:275582 )

N • normal baroreflex

N • normal vagus nerve cardiac modulation, as assessed by 2UV pattern occurrence in symbolic analysis of three-beat sequences

N • normal cardiac sympathetic modulation, as assessed by 0V pattern occurrence in symbolic analysis of three-beat sequences

abnormal parasympathetic nervous system physiology ( J:275582 )

• higher cardiac parasympathetic modulation, as assessed by 2LV pattern occurrence in symbolic analysis of three-beat sequences

• higher cardiac sympathetic and parasympathetic modulation, as assessed by 1V pattern occurrence in symbolic analysis of three-beat sequences

abnormal sympathetic nervous system physiology ( J:275582 )

• higher cardiac sympathetic and parasympathetic modulation, as assessed by 1V pattern occurrence in symbolic analysis of three-beat sequences

• normal cardiac sympathetic modulation, as assessed by 0V pattern occurrence in symbolic analysis of three-beat sequences