Phenotypes associated with this allele

• Allele Symbol: tsl
• Allele Name: tremor with short lifespan
• Allele ID: MGI:6314192
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	tsl/tsl	B6NTacTcu.CByJNarl-tsl	MGI:6314273
hm2	tsl/tsl	CByJNarl(B6NTacTcu)-tsl	MGI:6314274

Genotype
MGI:6314273

hm1

• Allelic Composition: tsl/tsl
• Genetic Background: B6NTacTcu.CByJNarl-tsl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:275934 )

• average lifespan is only 10 days; maximum 12 days

hematopoietic system

abnormal hemopoiesis ( J:275934 )

• in bone marrow or spleen or liver

growth/size/body

decreased body weight ( J:275934 )

behavior/neurological

abnormal gait ( J:275934 )

cellular

abnormal vacuole morphology ( J:275934 )

• vacuolizations in various cells, may indicate the results of wasting syndrome

integument

pallor ( J:275934 )

• indicating anemia

skeleton

decreased width of hypertrophic chondrocyte zone ( J:275934 )

• absent

Genotype
MGI:6314274

hm2

• Allelic Composition: tsl/tsl
• Genetic Background: CByJNarl(B6NTacTcu)-tsl

mortality/aging

premature death ( J:275934 )

• average lifespan is 38 days; maximum 44 days

behavior/neurological

tremors ( J:275934 )

• around 10 to 14 days of age

ataxia ( J:275934 )

• around 10 to 14 days of age

seizures ( J:275934 )

• prior to death in some mice

hematopoietic system

abnormal hemopoiesis ( J:275934 )

• in bone marrow or spleen or liver

cellular

abnormal vacuole morphology ( J:275934 )

• vacuolization in skeletal and caridiac muscle cells, hepatocytes, renal tubular cells, enterocytes etc. may indicate the results of wasting syndrome

nervous system

seizures ( J:275934 )

• prior to death in some mice

dysmyelination ( J:275934 )

• hypomyelination in CNS only

integument

pallor ( J:275934 )

• pale skin and mucosa (indicating anemia)