Phenotypes associated with this allele

• Allele Symbol: Deptor^tm1.1Mala
• Allele Name: targeted mutation 1.1, Mathieu Laplante
• Allele ID: MGI:6314233
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Deptor^tm1.1Mala/Deptor^tm1.1Mala Speer6-ps1^Tg(Alb-cre)21Mgn/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 x DBA	MGI:6314564

Genotype
MGI:6314564

cn1

• Allelic Composition: Deptor^tm1.1Mala/Deptor^tm1.1Mala; Speer6-ps1^{Tg(Alb-cre)21Mgn}/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 x DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:275931 )

N • normal fasting circulating insulin, triglyceride and non-esterified fatty acid levels

N • normal food intake

N • normal skeletal muscle glycogen deposition after fasting

N • normal liver triglyceride levels after fasting

decreased fasting circulating glucose level ( J:275931 )

• transient reduction in fasting glucose levels

• normal after extended fasting

• normal after refeeding

decreased liver glycogen level ( J:275931 )

• lower hepatic glycogen deposition after fasting

• rapid normalization of glycogen levels when given access to food after fasting

increased insulin sensitivity ( J:275931 )

• reduction in circulating glucose after intraperitoneal injection of insulin

liver/biliary system

liver/biliary system phenotype ( J:275931 )

N • normal liver size

decreased liver glycogen level ( J:275931 )

• lower hepatic glycogen deposition after fasting

• rapid normalization of glycogen levels when given access to food after fasting

growth/size/body

growth/size/body region phenotype ( J:275931 )

N • normal body weight and liver size