Phenotypes associated with this allele

• Allele Symbol: Nkx2-5^tm1.1Krc
• Allele Name: targeted mutation 1.1, Kenneth R Chien
• Allele ID: MGI:6314342
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Nkx2-5^tm1.1Krc/Nkx2-5^+	129S2.Cg(FVB)-Nkx2-5^tm1.1Krc	MGI:6314343

Genotype
MGI:6314343

ht1

• Allelic Composition: Nkx2-5^tm1.1Krc/Nkx2-5⁺
• Genetic Background: 129S2.Cg(FVB)-Nkx2-5^tm1.1Krc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal tricuspid valve morphology ( J:273096 )

• 11% of newborns exhibit incomplete delamination of tricuspid valve

abnormal tricuspid valve cusp morphology ( J:273096 )

• 6% of newborns exhibit apical displacement of septal leaflet of tricuspid valve

abnormal heart ventricle morphology ( J:273096 )

• 33% of newborns exhibit ventricular noncompaction

perimembraneous ventricular septal defect ( J:273096 )

• 33% of newborns exhibit perimembranous or muscular ventricular septal defects

muscular ventricular septal defect ( J:273096 )

• 33% of newborns exhibit perimembranous or muscular ventricular septal defects

mortality/aging

mortality/aging ( J:273096 )

N • perinatal death is not observed