Phenotypes associated with this allele

• Allele Symbol: Calm1^em1Gkim
• Allele Name: endonuclease-mediated mutation 1, Geumsoo Kim
• Allele ID: MGI:6315239
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Calm1^em1Gkim/Calm1^em1Gkim	C57BL/6N-Calm1^em1Gkim	MGI:6315260

Genotype
MGI:6315260

hm1

• Allelic Composition: Calm1^em1Gkim/Calm1^em1Gkim
• Genetic Background: C57BL/6N-Calm1^em1Gkim

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased body fat mass ( J:272366 )

• mice increase in fat mass with age and decrease in lean mass

behavior/neurological

behavior/neurological phenotype ( J:272366 )

N • mice exhibit behavior similar to controls in tests of associative learning (Pavlovian conditioning) and spatial learning (morris water maze)

increased exploration in new environment ( J:272366 )

• in the open field test of spontaneous activity, mice exhibit increased exploration of the central area, are more active and travel farther

hyperactivity ( J:272366 )

• mice exhibit increased activity by 2 months of age, however, activity decreases by 10 months of age

cardiovascular system

increased heart rate ( J:272366 )

♀ • heart rate in female mice is slightly increased at 6 months of age as compared to controls

homeostasis/metabolism

increased aerobic running capacity ( J:272366 )

• mice run 20% longer and with a 30% increase in total distance as compared to controls at 6 months of age

• females run slightly faster than female controls

growth/size/body

increased body fat mass ( J:272366 )

• mice increase in fat mass with age and decrease in lean mass

decreased lean body mass ( J:272366 )

• mice increase in fat mass with age and decrease in lean mass

increased body weight ( J:272366 )

• mice become heavier as they age as compared to controls

decreased body size ( J:272366 )

• males and females are 20% smaller than controls between 2-4 months of age