Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-Naa10)10Jprk
• Allele Name: transgene insertion 10, Jong-Wan Park
• Allele ID: MGI:6315314
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(CAG-Naa10)10Jprk/0	involves: C57BL/6	MGI:6715214

Genotype
MGI:6715214

tg1

• Allelic Composition: Tg(CAG-Naa10)10Jprk/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

impaired osteoblast differentiation ( J:276208 )

• primary osteoblasts show inhibition of differentiation in culture upon induction with BMP-2

abnormal osteoblast physiology ( J:276208 )

• osteoblast surface per bone surface is lower in calvaria but the osteoblast number per bone perimeter is not altered indicating that bone development is delayed in calvarias because osteoblasts are less active

abnormal neurocranium morphology ( J:276208 )

• calvarial area and density are reduced

abnormal fontanelle morphology ( J:276208 )

• calvarial fontanels are less closed and the bones are less dense

abnormal femur morphology ( J:276208 )

• femurs are less developed on P3

decreased bone mineral density ( J:276208 )

• calvarial density is reduced

craniofacial

abnormal neurocranium morphology ( J:276208 )

• calvarial area and density are reduced

abnormal fontanelle morphology ( J:276208 )

• calvarial fontanels are less closed and the bones are less dense

limbs/digits/tail

abnormal femur morphology ( J:276208 )

• femurs are less developed on P3

cellular

impaired osteoblast differentiation ( J:276208 )

• primary osteoblasts show inhibition of differentiation in culture upon induction with BMP-2

abnormal osteoblast physiology ( J:276208 )

• osteoblast surface per bone surface is lower in calvaria but the osteoblast number per bone perimeter is not altered indicating that bone development is delayed in calvarias because osteoblasts are less active