Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-DFFB)1Khu
• Allele Name: transgene insertion 1, Kai Huang
• Allele ID: MGI:6315918
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-DFFB)1Khu/0	Not Specified	MGI:6315921

Genotype
MGI:6315921

tg1

• Allelic Composition: Tg(Myh6-DFFB)1Khu/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased response of heart to induced stress ( J:259377 )

• mice show an aggravated cardiac hypertrophic response to pressure overload induced by chronic aortic banding as evidenced by an increase in cardiomyocyte size and higher ratios of heart weight/body weight, heart weight/tibia length, and lung weight/body weight, increase in cardiac hypertrophy markers, impaired cardiac structure and function and increase in cardiac fibrotic response

• however, under basal conditions, mice are healthy and show no cardiac morphological or pathological abnormalities

homeostasis/metabolism

increased response of heart to induced stress ( J:259377 )

• mice show an aggravated cardiac hypertrophic response to pressure overload induced by chronic aortic banding as evidenced by an increase in cardiomyocyte size and higher ratios of heart weight/body weight, heart weight/tibia length, and lung weight/body weight, increase in cardiac hypertrophy markers, impaired cardiac structure and function and increase in cardiac fibrotic response

• however, under basal conditions, mice are healthy and show no cardiac morphological or pathological abnormalities