Phenotypes associated with this allele

• Allele Symbol: Pcsk2^em1(IMPC)H
• Allele Name: endonuclease-mediated mutation 1, Harwell
• Allele ID: MGI:6316118
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pcsk2^em1(IMPC)H/Pcsk2^em1(IMPC)H	C57BL/6NTac-Pcsk2^em1(IMPC)H/H	MGI:6408558
ht2	Pcsk2^em1(IMPC)H/Pcsk2^+	C57BL/6NTac-Pcsk2^em1(IMPC)H/H	MGI:6772011

Genotype
MGI:6408558

hm1

• Allelic Composition: Pcsk2^em1(IMPC)H/Pcsk2^em1(IMPC)H
• Genetic Background: C57BL/6NTac-Pcsk2^em1(IMPC)H/H

Data Sources

IMPC Data for Pcsk2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

limb grasping ( J:211773 )

♀

IMPC - HAR

abnormal locomotor behavior ( J:211773 )

IMPC - HAR

hematopoietic system

increased mean corpuscular volume ( J:211773 )

♀

IMPC - HAR

homeostasis/metabolism

decreased circulating glucose level ( J:211773 )

♀

IMPC - HAR

increased circulating cholesterol level ( J:211773 )

♀

IMPC - HAR

increased circulating HDL cholesterol level ( J:211773 )

♀

IMPC - HAR

increased circulating iron level ( J:211773 )

♀

IMPC - HAR

increased circulating amylase level ( J:211773 )

♀

IMPC - HAR

integument

abnormal coat/ hair morphology ( J:211773 )

♀

IMPC - HAR

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - HAR

Genotype
MGI:6772011

ht2

• Allelic Composition: Pcsk2^em1(IMPC)H/Pcsk2⁺
• Genetic Background: C57BL/6NTac-Pcsk2^em1(IMPC)H/H

Data Sources

IMPC Data for Pcsk2

homeostasis/metabolism

increased circulating alanine transaminase level ( J:211773 )

♂

IMPC - HAR