Phenotypes associated with this allele

• Allele Symbol: Cyrib^{tm1c(KOMP)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:6316275
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cyrib^tm1c(KOMP)Wtsi/Cyrib^tm1d(KOMP)Wtsi Lyz2^tm1(cre)Ifo/Lyz2^+	involves: 129P2/OlaHsd * 129S4/SvJaeSor * BcA17/Skmn * C57BL/6N	MGI:6445568

Genotype
MGI:6445568

cn1

• Allelic Composition: Cyrib^{tm1c(KOMP)Wtsi}/Cyrib^{tm1d(KOMP)Wtsi}; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BcA17/Skmn * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal actin cytoskeleton morphology ( J:282597 )

• change in actin cytoskeleton remodeling causing significant increase in percentage of Salmonella-infected cells and cells harbouring more than one bacterium per cell when bone marrow derived macrophages (BMDMs) were subjected to opsonized S. Typhimurium infection

• normal percentage of Salmonella-infected cells and cells harbouring more than one bacterium per cell when cytochalasin D pre-treated BMDMs were subjected to opsonized S. Typhimurium infection

hematopoietic system

abnormal neutrophil physiology ( J:282597 )

• increased mobility in collagen matrix in vitro

immune system

abnormal neutrophil physiology ( J:282597 )

• increased mobility in collagen matrix in vitro

abnormal circulating chemokine level ( J:282597 )

• increased levels of CXCL2, CXCL10, CCL3, CCL4 and CCL5 after intravenous infection with Salmonella Typhimurium

increased circulating CXCL10 level ( J:282597 )

• increased levels of CXCL10 after intravenous infection with Salmonella Typhimurium

increased circulating interleukin-10 level ( J:282597 )

• after intravenous infection with Salmonella Typhimurium

increased circulating interleukin-6 level ( J:282597 )

• after intravenous infection with Salmonella Typhimurium

increased circulating tumor necrosis factor level ( J:282597 )

• increased levels of TNFA after intravenous infection with Salmonella Typhimurium

increased susceptibility to bacterial infection induced morbidity/mortality ( J:282597 )

• progressive increase in bacterial load, overall and in spleen and liver after intravenous or oral infection with Salmonella Typhimurium

• decreased survival rates after intravenous or oral infection with Salmonella Typhimurium

• higher bacterial load in lungs after infection with M. tuberculosis

• increased parenchymal infiltration by granulomatous reaction and lympho-histiocytic inflammatory cells in lungs after infection with M. tuberculosis

homeostasis/metabolism

abnormal circulating chemokine level ( J:282597 )

• increased levels of CXCL2, CXCL10, CCL3, CCL4 and CCL5 after intravenous infection with Salmonella Typhimurium

increased circulating CXCL10 level ( J:282597 )

• increased levels of CXCL10 after intravenous infection with Salmonella Typhimurium

increased circulating interleukin-10 level ( J:282597 )

• after intravenous infection with Salmonella Typhimurium

increased circulating interleukin-6 level ( J:282597 )

• after intravenous infection with Salmonella Typhimurium

increased circulating tumor necrosis factor level ( J:282597 )

• increased levels of TNFA after intravenous infection with Salmonella Typhimurium

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:282597 )

• progressive increase in bacterial load, overall and in spleen and liver after intravenous or oral infection with Salmonella Typhimurium

• decreased survival rates after intravenous or oral infection with Salmonella Typhimurium

• higher bacterial load in lungs after infection with M. tuberculosis

• increased parenchymal infiltration by granulomatous reaction and lympho-histiocytic inflammatory cells in lungs after infection with M. tuberculosis

respiratory system

pulmonary parenchymal consolidation ( J:282597 )

• large parenchymal consolidation in lungs after infection with M. tuberculosis