Phenotypes associated with this allele

• Allele Symbol: Plcg2^em1Msasn
• Allele Name: endonuclease-mediated mutation 1, Michael Sasner
• Allele ID: MGI:6316314
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plcg2^em1Msasn/Plcg2^em1Msasn	B6.Cg-Plcg2^em1Msasn/J	MGI:6741044

Genotype
MGI:6741044

hm1

• Allelic Composition: Plcg2^em1Msasn/Plcg2^em1Msasn
• Genetic Background: B6.Cg-Plcg2^em1Msasn/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal endocytosis ( J:308279 )

• enhanced endocytic clearance of amyloid beta 1-42 oligomers and 10 kDa dextran in macrophages and microglia

impaired macrophage phagocytosis ( J:308279 )

• reduced phagocytosis of E. Coli and zymosan particles

hematopoietic system

impaired macrophage phagocytosis ( J:308279 )

• reduced phagocytosis of E. Coli and zymosan particles

homeostasis/metabolism

abnormal calcium level ( J:308279 )

• greater increase in intracellular calcium levels in microglia cultured from neonatal cortex and hippocampus after anti-Fcgr2b/3 exposure

• greater increase in intracellular calcium levels in microglia and macrophages after stimulation with LPS or high dose of amyloid beta 1-42 oligomers

immune system

impaired macrophage phagocytosis ( J:308279 )

• reduced phagocytosis of E. Coli and zymosan particles