Phenotypes associated with this allele

• Allele Symbol: Opalin^tm1Tfr
• Allele Name: targeted mutation 1, Teiichi Furuichi
• Allele ID: MGI:6322964
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Opalin^tm1Tfr/Opalin^tm1Tfr	B6.129P2-Opalin^tm1Tfr	MGI:6359784

Genotype
MGI:6359784

hm1

• Allelic Composition: Opalin^tm1Tfr/Opalin^tm1Tfr
• Genetic Background: B6.129P2-Opalin^tm1Tfr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:257142 )

N • male mice show normal basic sensory and motor activities with no differences in sensory reflex, circadian rhythm, locomotor activity in the home cage, anxiety- or depression-like behavior relative to wild-type controls

N • no epilepsy-like phenotypes are observed under ordinary breeding conditions

increased exploration in new environment ( J:257142 )

• in the open-field test, male mice are more active in the first 5 min and spend more time in the center area relative to wild-type controls

• however, no significant differences are observed in the light/dark transition

nervous system

nervous system phenotype ( J:257142 )

N • surprisingly, mice show no apparent differences in CNS myelination and oligodendrocyte maturation

N • optic nerves are normal in terms of fine structures of paranodal loops, transverse bands, and multi-lamellae of myelinated axons

growth/size/body

growth/size/body region phenotype ( J:257142 )

N • mice grow normally with no differences in body shape and weight relative to wild-type controls