Phenotypes associated with this allele

• Allele Symbol: Eif5b^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:6324040
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eif5b^em1(IMPC)J/Eif5b^em1(IMPC)J	C57BL/6NJ-Eif5b^em1(IMPC)J/Mmjax	MGI:6492819

Genotype
MGI:6492819

hm1

• Allelic Composition: Eif5b^em1(IMPC)J/Eif5b^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Eif5b^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Eif5b

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Eif5b^em1(IMPC)J/Eif5b^em1(IMPC)J mice exhibit embryonic lethality, with no embryos detected at E7.5 and lower number of embryos than expected at E3.5 that appear as morulae. Blastocysts grown in vitro fail to hatch from the zona pellucida.

embryo

failure of blastocyst formation ( J:279207 )

• in vitro, embryos fail to form blastocysts and are dead after 3 days in culture

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro, embryos fail to hatch from the zona pellucida after 3 days in culture

embryonic growth retardation ( J:279207 )

• embryos recovered at E3.5 appear as morulae

growth/size/body

embryonic growth retardation ( J:279207 )

• embryos recovered at E3.5 appear as morulae

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality before implantation, complete penetrance ( J:279207 )

• homozygous embryos are recovered at lower than expected Mendelian ratios at E3.5 (9% versus 25%, n=33) and appear as morulae; no homozygous embryos or excess resorption sites are observed at E7.5