Analysis Tools
reproductive system
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• female homozygotes exhibit normal fertility
• male homozygotes show normal seminal vesicle morphology and weight
• cauda epididymal spermatozoa show normal morphology and motility parameters with no defects in in vitro or in vivo fertilizing ability
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• 2 h after mating, the number of ejaculated spermatozoa in the uterus is significantly lower than that for control males
• however, the total sperm count stored in the cauda epididymis is normal
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• when male homozygotes are caged with wild-type females, the average litter size is significantly lower than that for wild-type or heterozygous control males
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• male homozygotes are subfertile; when caged with wild-type females, the number of litters/female/month of caging is significantly lower than that for wild-type or heterozygous control males
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behavior/neurological
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• male homozygotess form significantly smaller copulatory plugs relative to wild-type or heterozygous control males; however, the amount of copulatory plug-related proteins SVS1 to SVS3 and TGM4 are normal
• abnormal copulatory plug formation leads to semen leakage and a decreased sperm count in the uterus
• females mated with male homozygotes become pregnant in subsequent matings with wild-type males
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