Phenotypes associated with this allele

• Allele Symbol: Pth2r^tm1.1Tbu
• Allele Name: targeted mutation 1.1, Ted B Usdin
• Allele ID: MGI:6330764
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pth2r^tm1.1Tbu/Pth2r^tm1.1Tbu	involves: 129 * 129S4/SvJae * C57BL/6	MGI:6330781

Genotype
MGI:6330781

hm1

• Allelic Composition: Pth2r^tm1.1Tbu/Pth2r^tm1.1Tbu
• Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:277091 )

♀N • normal rearing, exploring, sniffing, freezing, stillness, and stretch attend behavior and time spent in center and margins during open field test

♀N • normal pup retrieval activity and other maternal behavior (licking-grooming, arched back or passive nursing)

abnormal behavior ( J:277091 )

♀ • much reduced time spent out of nest

abnormal depression-related behavior ( J:277091 )

♀ • enhanced depressive-like behavior (floating) and reduced non-depressive-like behavior (struggling) of mothers during forced swim test (tested between postnatal day 7-10)

decreased grooming behavior ( J:277091 )

♀ • decreased time spent self-cleaning during open field test (performed between postnatal day 14-17)

abnormal locomotor behavior ( J:277091 )

♀ • increased distance travelled and velocity during open field test (performed between postnatal day 14-17)

abnormal locomotor circadian rhythm ( J:277091 )

♀ • higher levels of locomotion in prepartum, early lactation (postpartum day 3-5) and late lactation (ppd 13-16) stage females during both light and dark phases

♀ • normal in virgin females during both light and dark phases

homeostasis/metabolism

decreased core body temperature ( J:277091 )

♀ • in prepartum and early lactation (postpartum day 3-5) stage females during both light and dark phases

♀ • in late lactation (postpartum day 13-16) stage females during dark phase

♀ • in virgin females during both light and dark phases