Phenotypes associated with this allele

• Allele Symbol: Ctsa^{tm2b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 2b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:6336220
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ctsa^tm2b(EUCOMM)Hmgu/Ctsa^tm2b(EUCOMM)Hmgu	C57BL/6N-Ctsa^tm2b(EUCOMM)Hmgu/H	MGI:6696702

Genotype
MGI:6696702

hm1

• Allelic Composition: Ctsa^{tm2b(EUCOMM)Hmgu}/Ctsa^{tm2b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Ctsa^{tm2b(EUCOMM)Hmgu}/H
• Cell Lines: HEPD0507_5_A09

Data Sources

IMPC Data for Ctsa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired cued conditioning behavior ( J:211773 )

♀

IMPC - HAR

decreased exploration in new environment ( J:211773 )

IMPC - HAR

abnormal freezing behavior ( J:211773 )

♀

IMPC - HAR

increased freezing behavior ( J:211773 )

IMPC - HAR

abnormal startle reflex ( J:211773 )

♀

IMPC - HAR

decreased startle reflex ( J:211773 )

♂

IMPC - HAR

tremors ( J:211773 )

IMPC - HAR

abnormal locomotor behavior ( J:211773 )

♂

IMPC - HAR

abnormal gait ( J:211773 )

♂

IMPC - HAR

decreased locomotor activity ( J:211773 )

IMPC - HAR

cardiovascular system

increased heart weight ( J:211773 )

IMPC - HAR

decreased heart rate ( J:211773 )

IMPC - HAR

prolonged RR interval ( J:211773 )

IMPC - HAR

growth/size/body

increased heart weight ( J:211773 )

IMPC - HAR

abnormal head morphology ( J:211773 )

IMPC - HAR

enlarged spleen ( J:211773 )

♀

IMPC - HAR

increased spleen weight ( J:211773 )

IMPC - HAR

hematopoietic system

enlarged spleen ( J:211773 )

♀

IMPC - HAR

increased spleen weight ( J:211773 )

IMPC - HAR

decreased erythrocyte cell number ( J:211773 )

IMPC - HAR

decreased hematocrit ( J:211773 )

♂

IMPC - HAR

decreased hemoglobin content ( J:211773 )

♂

IMPC - HAR

increased mean corpuscular hemoglobin ( J:211773 )

♀

IMPC - HAR

increased mean corpuscular volume ( J:211773 )

♀

IMPC - HAR

thrombocytopenia ( J:211773 )

IMPC - HAR

increased monocyte cell number ( J:211773 )

IMPC - HAR

homeostasis/metabolism

increased circulating bilirubin level ( J:211773 )

IMPC - HAR

decreased circulating glucose level ( J:211773 )

♂

IMPC - HAR

decreased circulating cholesterol level ( J:211773 )

♀

IMPC - HAR

decreased circulating HDL cholesterol level ( J:211773 )

IMPC - HAR

decreased circulating triglyceride level ( J:211773 )

♂

IMPC - HAR

decreased circulating calcium level ( J:211773 )

IMPC - HAR

increased circulating iron level ( J:211773 )

IMPC - HAR

increased circulating potassium level ( J:211773 )

IMPC - HAR

increased circulating alanine transaminase level ( J:211773 )

IMPC - HAR

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - HAR

increased circulating aspartate transaminase level ( J:211773 )

IMPC - HAR

decreased circulating serum albumin level ( J:211773 )

♀

IMPC - HAR

decreased circulating total protein level ( J:211773 )

IMPC - HAR

immune system

enlarged spleen ( J:211773 )

♀

IMPC - HAR

increased spleen weight ( J:211773 )

IMPC - HAR

increased monocyte cell number ( J:211773 )

IMPC - HAR

limbs/digits/tail

abnormal forelimb morphology ( J:211773 )

♂

IMPC - HAR

abnormal hindlimb morphology ( J:211773 )

♂

IMPC - HAR

nervous system

decreased prepulse inhibition ( J:211773 )

♀

IMPC - HAR

vision/eye

narrow eye opening ( J:211773 )

IMPC - HAR