Phenotypes associated with this allele

• Allele Symbol: Zc3h8^{em1(IMPC)Ccpcz}
• Allele Name: endonuclease-mediated mutation 1, Institute of Molecular Genetics
• Allele ID: MGI:6341865
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zc3h8^em1(IMPC)Ccpcz/Zc3h8^em1(IMPC)Ccpcz	C57BL/6N-Zc3h8^em1(IMPC)Ccpcz/Ccpcz	MGI:6696978
ht2	Zc3h8^em1(IMPC)Ccpcz/Zc3h8^+	C57BL/6N-Zc3h8^em1(IMPC)Ccpcz/Ccpcz	MGI:6696977

Genotype
MGI:6696978

hm1

• Allelic Composition: Zc3h8^{em1(IMPC)Ccpcz}/Zc3h8^{em1(IMPC)Ccpcz}
• Genetic Background: C57BL/6N-Zc3h8^{em1(IMPC)Ccpcz}/Ccpcz

Data Sources

IMPC Data for Zc3h8

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - CCP-IMG

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - CCP-IMG

preweaning lethality, complete penetrance ( J:211773 )

IMPC - CCP-IMG

Genotype
MGI:6696977

ht2

• Allelic Composition: Zc3h8^{em1(IMPC)Ccpcz}/Zc3h8⁺
• Genetic Background: C57BL/6N-Zc3h8^{em1(IMPC)Ccpcz}/Ccpcz

Data Sources

IMPC Data for Zc3h8

cardiovascular system

abnormal heart morphology ( J:211773 )

♂

IMPC - CCP-IMG

enlarged heart ( J:211773 )

♂

IMPC - CCP-IMG

growth/size/body

enlarged heart ( J:211773 )

♂

IMPC - CCP-IMG

enlarged kidney ( J:211773 )

♀

IMPC - CCP-IMG

enlarged liver ( J:211773 )

♂

IMPC - CCP-IMG

enlarged spleen ( J:211773 )

♀

IMPC - CCP-IMG

hematopoietic system

decreased CD8-positive, naive alpha-beta T cell number ( J:211773 )

♂

IMPC - CCP-IMG

abnormal spleen morphology ( J:211773 )

♀

IMPC - CCP-IMG

enlarged spleen ( J:211773 )

♀

IMPC - CCP-IMG

immune system

decreased CD8-positive, naive alpha-beta T cell number ( J:211773 )

♂

IMPC - CCP-IMG

abnormal spleen morphology ( J:211773 )

♀

IMPC - CCP-IMG

enlarged spleen ( J:211773 )

♀

IMPC - CCP-IMG

integument

abnormal skin morphology ( J:211773 )

IMPC - CCP-IMG

limbs/digits/tail

abnormal digit morphology ( J:211773 )

IMPC - CCP-IMG

liver/biliary system

abnormal liver morphology ( J:211773 )

♂

IMPC - CCP-IMG

enlarged liver ( J:211773 )

♂

IMPC - CCP-IMG

renal/urinary system

abnormal kidney morphology ( J:211773 )

♀

IMPC - CCP-IMG

enlarged kidney ( J:211773 )

♀

IMPC - CCP-IMG

single kidney ( J:211773 )

♀

IMPC - CCP-IMG

skeleton

lordosis ( J:211773 )

IMPC - CCP-IMG