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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nell1tm1Kuv
targeted mutation 1, Universitat Kiel
MGI:6341975
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Nell1tm1Kuv/Nell1tm1Kuv
Rb1tm2Brn/Rb1tm2Brn
Trp53tm1Brn/Trp53tm1Brn
Tg(BGLAP-cre)1Clem/0 		involves: 129 * FVB/NJ MGI:7482567


Genotype
MGI:7482567
cn1
Allelic
Composition		 Nell1tm1Kuv/Nell1tm1Kuv
Rb1tm2Brn/Rb1tm2Brn
Trp53tm1Brn/Trp53tm1Brn
Tg(BGLAP-cre)1Clem/0
Genetic
Background		 involves: 129 * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nell1tm1Kuv mutation (1 available); any Nell1 mutation (57 available)
Rb1tm2Brn mutation (3 available); any Rb1 mutation (111 available)
Tg(BGLAP-cre)1Clem mutation (1 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased tumor-free survival time ( J:326989 )
• tumor-free survival is 398 days compared to 146.5 days in mutant mice wild-type for Nell1

neoplasm
abnormal tumor morphology ( J:326989 )
• 85.2% decrease in the proliferative-index in tumors compared to tumors in mutant mice wild-type for Nell1
abnormal tumor vascular morphology ( J:326989 )
• 66.1% decrease in tumor-associated vasculature compared to mutant mice wild-type for Nell1
decreased osteosarcoma incidence ( J:326989 )
• 15.8% incidence compared to 52.4% incidence in mutant mice wild-type for Nell1

skeleton
decreased osteosarcoma incidence ( J:326989 )
• 15.8% incidence compared to 52.4% incidence in mutant mice wild-type for Nell1




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory