Phenotypes associated with this allele

• Allele Symbol: Gja8^Aey69
• Allele Name: abnormal eyes 69
• Allele ID: MGI:6342052
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Gja8^Aey69/Gja8^Aey69 H3c14^Aey69/H3c14^Aey69	C3HeB/FeJ	MGI:6342121

Genotype
MGI:6342121

cx1

• Allelic Composition: Gja8^Aey69/Gja8^Aey69; H3c14^Aey69/H3c14^Aey69
• Genetic Background: C3HeB/FeJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal cornea morphology ( J:277247 )

• failure of detachment of transient connection between surface ectoderm (future cornea) and lens vesicle at age E13.5

increased cornea thickness ( J:277247 )

• at age E15.5

abnormal lens development ( J:277247 )

• lens vesicle filled with pycnotic and disorganized cells at age E13.5

microphthalmia ( J:277247 )

• small and disorganized lens vesicle starting in embryos age E11.5

• normal formation of lens vesicle in embryos age E10.5

abnormal retina morphology ( J:277247 )

• abnormal bending of retinal layers anterior to cornea at age E17.5

• retinal pigmented epithelium (RPE) covering entire anterior part of eye at age P1

• establishment of outer and inner neuroblastic layers in neural retina

retina hyperplasia ( J:277247 )

• thicker and larger retina at age E17.5

• post-partum invasion of central part of the eye (filling up lens and vitreous space) by RPE and other retinal layers

embryo

embryo phenotype ( J:277247 )

N • viable

growth/size/body

decreased body mass index ( J:277247 )

homeostasis/metabolism

hypolipidemia ( J:277247 )

• reduced blood lipid levels (hypolipidemia)

increased body temperature ( J:277247 )

reproductive system

reproductive system phenotype ( J:277247 )

N • fertile

behavior/neurological

decreased anxiety-related response ( J:277247 )

increased vertical activity ( J:277247 )

• increased rearing

increased locomotor activity ( J:277247 )

• increased locomotor activity