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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Erp29tm1Dfer
targeted mutation 1, David Ferrari
MGI:6342880
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Erp29tm1Dfer/Erp29tm1Dfer involves: 129S2/SvPas * C57BL/6N MGI:6380521


Genotype
MGI:6380521
hm1
Allelic
Composition		 Erp29tm1Dfer/Erp29tm1Dfer
Genetic
Background		 involves: 129S2/SvPas * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erp29tm1Dfer mutation (0 available); any Erp29 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased sensitivity to induced cell death ( J:217253 )
• adult thyrocytes show lower apoptosis sensitivitiy than wild-type cells when treated with tunicamycin to induce ER stress
decreased cellular sensitivity to hydrogen peroxide ( J:217253 )
• dermal fibroblasts show lower apoptosis sensitivities than wild-type cells when treated with hydrogen peroxide

reproductive system
decreased litter size ( J:217253 )
• mean litter size is slightly reduced (5.2 +/- 3.1 in wild-type vs. 4.6 +/- 2.8 in mutants)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory