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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Snrnp70em1(IMPC)Bay
endonuclease-mediated mutation 1, Baylor College of Medicine
MGI:6342907
Summary 2 genotypes


Genotype
MGI:7388757
hm1
Allelic
Composition
Snrnp70em1(IMPC)Bay/Snrnp70em1(IMPC)Bay
Genetic
Background
C57BL/6N-Snrnp70em1(IMPC)Bay/BayMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snrnp70em1(IMPC)Bay mutation (1 available); any Snrnp70 mutation (39 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7720103
hm2
Allelic
Composition
Snrnp70em1(IMPC)Bay/Snrnp70em1(IMPC)Bay
Genetic
Background
C57BL/6N-Snrnp70em1(IMPC)Bay/Mmmh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snrnp70em1(IMPC)Bay mutation (1 available); any Snrnp70 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Snrnp70em1(IMPC)Bay/Snrnp70em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 but not at E7.5. Embryos at E3.5 appear as morulae. Mutants fail to hatch from the zona pellucida and and die after 3 days in culture.

mortality/aging
• homozygous embryos are recovered at E3.5 (16% versus expected 25%, n=19) and appear as morulae; no homozygous embryos or excess resorption sites are observed at E7.5

embryo
• in vitro, embryos fail to hatch from the zona pellucida and are dead after 3 days in culture
• embryos recovered at E3.5 appear as morulae

growth/size/body
• embryos recovered at E3.5 appear as morulae





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory