Analysis Tools|
Allele Symbol Allele Name Allele ID |
Cog1em1(IMPC)Bay endonuclease-mediated mutation 1, Baylor College of Medicine MGI:6342908 |
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| Summary |
2 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Cog1em1(IMPC)Bay/Cog1em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida but form irregular outgrowths with a poorly defined inner cell mass after 3 days in culture.
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• early blastocysts are present at E3.5 (17% versus expected 25%, n=42); no homozygous embryos are recovered at E7.5
• however, excess resorption sites suggest that embryos elicit a decidual response in vivo
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• in vitro outgrowth assays show a poorly defined ICM after 3 days in culture
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• in vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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