Phenotypes associated with this allele

• Allele Symbol: Abhd4^tm1Crv
• Allele Name: targeted mutation 1, Benjamin F Cravatt
• Allele ID: MGI:6343190
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abhd4^tm1Crv/Abhd4^tm1Crv	B6.129S6-Abhd4^tm1Crv	MGI:6402161

Genotype
MGI:6402161

hm1

• Allelic Composition: Abhd4^tm1Crv/Abhd4^tm1Crv
• Genetic Background: B6.129S6-Abhd4^tm1Crv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:276423 )

• concentrations of several glycerophospho-N-acyl ethanolamines (GP-NAEs) are significantly decreased in brain, with the most prominent reduction seen in N-16:0 GP-NAE

• modest, but significant reductions of some lyso-N-acyl phosphatidylethanolamines (lyso-NAPEs), including N-16:0, O-18:0 and N-16:0, O-20:4, are detected in brain

• plasmalogen-type lyso-NAPE (lyso-pNAPE) content is markedly reduced in brain

• almost all of the O-16:0 and O-18:0 lyso-N-acyl phosphatidylserine (lyso-NAPS) species are severely reduced in brain tissue, including the most abundant N-16:0, O-18:0 and N-16:0, O-18:1 species

• modest but significant elevations are detected in several N-acyl phosphatidylserine (NAPS) lipids in brain tissue

• however, no significant changes in NAPE, N-acyl ethanolamine (NAE) or plasmalogen-type NAPE (pNAPE) content are observed in brain tissue and the abundance of lyso-NAPS species with unsaturated O-fatty acyl groups on the glycerol backbone as well as N-acyl serine species (NASs) is normal

abnormal enzyme/coenzyme activity ( J:276423 )

• brain homogenates show significant, but incomplete reductions in N-acyl phosphatidylethanolamine (NAPE)- and lyso-NAPE-lipase activity relative to those from wild-type controls

• brain lysates show significantly decreased pNAPE-lipase activity

behavior/neurological

behavior/neurological phenotype ( J:276423 )

N • mice are viable and healthy with no overt abnormalities in home cage behavior