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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ythdf3em1Caox
endonuclease-mediated mutation 1, Xuetao Cao
MGI:6343198
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ythdf3em1Caox/Ythdf3em1Caox involves: C57BL/6J MGI:6479099
cx2
 		Ifnar1tm1Agt/Ifnar1tm1Agt
Ythdf3em1Caox/Ythdf3em1Caox 		involves: C57BL/6J MGI:6479103


Genotype
MGI:6479099
hm1
Allelic
Composition		 Ythdf3em1Caox/Ythdf3em1Caox
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ythdf3em1Caox mutation (0 available); any Ythdf3 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:276397 )
N
• mice exhibit normal development of immune cells with no differences in the percentages of CD19+ B cells, CD4+ T cells, CD8+ T cells, NK cells, dendritic cells or macrophages detected in splenocytes relative to wild-type controls
abnormal macrophage physiology ( J:276397 )
• bone marrow-derived macrophages (BMDMs) show higher mRNA expression levels of IFN-stimulated genes Ifit1 and Mx1 than wild-type BMDMs
• however, mRNA expression of both Ifna4 and Ifnb1 is normal
decreased susceptibility to Riboviria infection ( J:276397 )
• following infection with vesicular stomatitis virus (VSV) , BMDMs show a significantly lower abundance of both VSV RNA and VSV-glycoprotein (VSV-G) protein relative to wild-type BMDMs; reduced levels of VSV-G are also seen in VSV-infected bone marrow-derived dendritic cells and mouse embryonic fibroblasts (MEFs)
• following challenge with VSV via tail i.v. injection, mice show significantly lower VSV replication and VSV titers in liver, spleen and lung than wild-type controls
• after lethal VSV infection, mice show significantly lower infiltration of inflammatory cells in the lung than wild-type controls
decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:276397 )
• after lethal VSV infection, mice show significantly longer survival time than wild-type controls

hematopoietic system
abnormal macrophage physiology ( J:276397 )
• bone marrow-derived macrophages (BMDMs) show higher mRNA expression levels of IFN-stimulated genes Ifit1 and Mx1 than wild-type BMDMs
• however, mRNA expression of both Ifna4 and Ifnb1 is normal

mortality/aging
decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:276397 )
• after lethal VSV infection, mice show significantly longer survival time than wild-type controls




Genotype
MGI:6479103
cx2
Allelic
Composition		 Ifnar1tm1Agt/Ifnar1tm1Agt
Ythdf3em1Caox/Ythdf3em1Caox
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifnar1tm1Agt mutation (11 available); any Ifnar1 mutation (60 available)
Ythdf3em1Caox mutation (0 available); any Ythdf3 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:276397 )
• following infection with vesicular stomatitis virus (VSV) , peritoneal macrophages from double mutant mice show abrogation of both the IFN-stimulated gene activation and enhanced antiviral response observed in single Ythdf3em1Caox homozygotes

hematopoietic system
abnormal macrophage physiology ( J:276397 )
• following infection with vesicular stomatitis virus (VSV) , peritoneal macrophages from double mutant mice show abrogation of both the IFN-stimulated gene activation and enhanced antiviral response observed in single Ythdf3em1Caox homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory