Analysis Tools
immune system
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• at day 42 after primary type-II collagen (IIC) immunization, the serum IIC-specific IgG level is significantly lower than that in wild-type controls
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• at day 42 after primary type-II collagen (IIC) immunization, the deposition of C3b in the ankle joints is significantly lower than that in wild-type controls
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• in vitro complement activation assays revealed that the alternative pathway (AP) is specifically suppressed in mutant sera relative to wild-type sera, as determined by C3b deposition
• however, C3 and factor B levels are comparable to those in wild-type sera
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• following induction of severe collagen-induced arthritis (CIA), mice show a comparable incidence of arthritis with a significantly lower severity score, milder pathological changes in ankle joints, and lower serum type-II collagen (IIC)-specific IgG levels than wild-type controls at day 42 after primary IIC immunization
• following induction of severe anti-collagen antibody-induced arthritis (CAIA), mice show decreased incidence of arthritis with delayed onset and significantly lower severity scores than wild-type controls at days 7 after anti-IIC mAb injection
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homeostasis/metabolism
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• at day 42 after primary type-II collagen (IIC) immunization, the deposition of C3b in the ankle joints is significantly lower than that in wild-type controls
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hematopoietic system
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• at day 42 after primary type-II collagen (IIC) immunization, the serum IIC-specific IgG level is significantly lower than that in wild-type controls
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skeleton
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• following induction of severe collagen-induced arthritis (CIA), mice show a comparable incidence of arthritis with a significantly lower severity score, milder pathological changes in ankle joints, and lower serum type-II collagen (IIC)-specific IgG levels than wild-type controls at day 42 after primary IIC immunization
• following induction of severe anti-collagen antibody-induced arthritis (CAIA), mice show decreased incidence of arthritis with delayed onset and significantly lower severity scores than wild-type controls at days 7 after anti-IIC mAb injection
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renal/urinary system
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• aged mice show no alterations in urine total protein levels as measured by the bicinchoninic acid (BCA) assay, indicating normal kidney function
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