All Phenotypes Fbxw11<tm1Nakay> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fbxw11^tm1Nakay
targeted mutation 1, Keiko Nakayama
MGI:6343251

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fbxw11^tm1Nakay/Fbxw11^tm1Nakay	B6.Cg-Fbxw11^tm1Nakay	MGI:6781879
cn2	Fbxw11^tm2Nakay/Fbxw11^tm1Nakay	B6.Cg-Fbxw11^tm2Nakay Fbxw11^tm1Nakay	MGI:6781888
cx3	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Fbxw11^tm1Nakay/Fbxw11^tm1Nakay	B6.Cg-Cdkn2a^tm1Rdp Fbxw11^tm1Nakay	MGI:6781883

Allelic Composition	Fbxw11^tm1Nakay/Fbxw11^tm1Nakay
Genetic Background	B6.Cg-Fbxw11^tm1Nakay

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw11^tm1Nakay mutation (0 available); any Fbxw11 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:228222 )

• although present at normal Mendelian ratios up to E9.5, homozygous mutant embryos are resorbed at E10.5, with no viable embryos detected at P0

embryo

embryonic growth arrest ( J:228222 )

• developmental arrest before E10.5

embryonic growth retardation ( J:228222 )

• embryos are developmentally delayed at E9.5

abnormal extraembryonic tissue physiology ( J:228222 )

• accumulation of Cdkn2a (an inhibitor of cell cycle progression, also known as p19^ARF) mRNA in the yolk sac at E9.5

growth/size/body

embryonic growth retardation ( J:228222 )

• embryos are developmentally delayed at E9.5

Allelic Composition	Fbxw11^tm2Nakay/Fbxw11^tm1Nakay
Genetic Background	B6.Cg-Fbxw11^tm2Nakay Fbxw11^tm1Nakay

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw11^tm1Nakay mutation (0 available); any Fbxw11 mutation (72 available)
Fbxw11^tm2Nakay mutation (0 available); any Fbxw11 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased fibroblast proliferation ( J:228222 )

• after Cre retrovirus infection (to delete the floxed allele), primary mouse embryonic fibroblasts (MEFs) derived from E13.5 embryos show significantly decreased cell proliferation relative to wild-type MEFs

• no differences in oncogene-induced cellular replicative senescence or apoptosis are observed

• defect in MEF proliferation can be rescued by beta-TrCP2 overexpression, but not by beta-TrCP1 overexpression

• arrest in MEF proliferation is induced by stabilization and abnormal accumulation of Cdkn2a (also known as p19^ARF)

Allelic Composition	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Fbxw11^tm1Nakay/Fbxw11^tm1Nakay
Genetic Background	B6.Cg-Cdkn2a^tm1Rdp Fbxw11^tm1Nakay

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Rdp mutation (6 available); any Cdkn2a mutation (67 available)
Fbxw11^tm1Nakay mutation (0 available); any Fbxw11 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:228222 )

• phenotype is stated to be identical to that of Fbxw11^tm1Nakay homozygotes, indicating that concomitant inactivation of Cdkn2a does not rescue the lethal phenotype

embryo

embryonic growth arrest ( J:228222 )

embryonic growth retardation ( J:228222 )

growth/size/body

embryonic growth retardation ( J:228222 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24