All Phenotypes Fbxw11<tm1Nakay> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fbxw11^tm1Nakay
targeted mutation 1, Keiko Nakayama
MGI:6343251

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fbxw11^tm1Nakay/Fbxw11^tm1Nakay	B6.Cg-Fbxw11^tm1Nakay	MGI:6781879
cn2	Fbxw11^tm2Nakay/Fbxw11^tm1Nakay	B6.Cg-Fbxw11^tm2Nakay Fbxw11^tm1Nakay	MGI:6781888
cx3	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Fbxw11^tm1Nakay/Fbxw11^tm1Nakay	B6.Cg-Cdkn2a^tm1Rdp Fbxw11^tm1Nakay	MGI:6781883

Allelic Composition	Fbxw11^tm1Nakay/Fbxw11^tm1Nakay
Genetic Background	B6.Cg-Fbxw11^tm1Nakay

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw11^tm1Nakay mutation (0 available); any Fbxw11 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:228222 )

• although present at normal Mendelian ratios up to E9.5, homozygous mutant embryos are resorbed at E10.5, with no viable embryos detected at P0

embryo

embryonic growth arrest ( J:228222 )

• developmental arrest before E10.5

embryonic growth retardation ( J:228222 )

• embryos are developmentally delayed at E9.5

abnormal extraembryonic tissue physiology ( J:228222 )

• accumulation of Cdkn2a (an inhibitor of cell cycle progression, also known as p19^ARF) mRNA in the yolk sac at E9.5

growth/size/body

embryonic growth retardation ( J:228222 )

• embryos are developmentally delayed at E9.5

Allelic Composition	Fbxw11^tm2Nakay/Fbxw11^tm1Nakay
Genetic Background	B6.Cg-Fbxw11^tm2Nakay Fbxw11^tm1Nakay

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw11^tm1Nakay mutation (0 available); any Fbxw11 mutation (72 available)
Fbxw11^tm2Nakay mutation (0 available); any Fbxw11 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased fibroblast proliferation ( J:228222 )

• after Cre retrovirus infection (to delete the floxed allele), primary mouse embryonic fibroblasts (MEFs) derived from E13.5 embryos show significantly decreased cell proliferation relative to wild-type MEFs

• no differences in oncogene-induced cellular replicative senescence or apoptosis are observed

• defect in MEF proliferation can be rescued by beta-TrCP2 overexpression, but not by beta-TrCP1 overexpression

• arrest in MEF proliferation is induced by stabilization and abnormal accumulation of Cdkn2a (also known as p19^ARF)

Allelic Composition	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Fbxw11^tm1Nakay/Fbxw11^tm1Nakay
Genetic Background	B6.Cg-Cdkn2a^tm1Rdp Fbxw11^tm1Nakay

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Rdp mutation (6 available); any Cdkn2a mutation (67 available)
Fbxw11^tm1Nakay mutation (0 available); any Fbxw11 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:228222 )

• phenotype is stated to be identical to that of Fbxw11^tm1Nakay homozygotes, indicating that concomitant inactivation of Cdkn2a does not rescue the lethal phenotype

embryo

embryonic growth arrest ( J:228222 )

embryonic growth retardation ( J:228222 )

growth/size/body

embryonic growth retardation ( J:228222 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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