Phenotypes associated with this allele

• Allele Symbol: Fbxw11^tm2Nakay
• Allele Name: targeted mutation 2, Keiko Nakayama
• Allele ID: MGI:6343252
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fbxw11^tm2Nakay/Fbxw11^tm1Nakay	B6.Cg-Fbxw11^tm2Nakay Fbxw11^tm1Nakay	MGI:6781888

Genotype
MGI:6781888

cn1

• Allelic Composition: Fbxw11^tm2Nakay/Fbxw11^tm1Nakay
• Genetic Background: B6.Cg-Fbxw11^tm2Nakay Fbxw11^tm1Nakay

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased fibroblast proliferation ( J:228222 )

• after Cre retrovirus infection (to delete the floxed allele), primary mouse embryonic fibroblasts (MEFs) derived from E13.5 embryos show significantly decreased cell proliferation relative to wild-type MEFs

• no differences in oncogene-induced cellular replicative senescence or apoptosis are observed

• defect in MEF proliferation can be rescued by beta-TrCP2 overexpression, but not by beta-TrCP1 overexpression

• arrest in MEF proliferation is induced by stabilization and abnormal accumulation of Cdkn2a (also known as p19^ARF)