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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nup88em1Jvd
endonuclease-mediated mutation 1, Jan MA van Deursen
MGI:6343328
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Nup88em1Jvd/Nup88+
Nup98tm1Jvd/Nup98+
Rae1tm1Jvd/Rae1+ 		involves: C57BL/6 MGI:6377639


Genotype
MGI:6377639
cx1
Allelic
Composition		 Nup88em1Jvd/Nup88+
Nup98tm1Jvd/Nup98+
Rae1tm1Jvd/Rae1+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nup88em1Jvd mutation (0 available); any Nup88 mutation (44 available)
Nup98tm1Jvd mutation (0 available); any Nup98 mutation (146 available)
Rae1tm1Jvd mutation (0 available); any Rae1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitosis ( J:231166 )
• chromosome segregation errors are reduced to 18% from 37% in double Rae1tm1Jvd Nup98tm1Jvd heterozygotes and the mitotic checkpoint is fully restored




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory