Analysis Tools
mortality/aging
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• although present at expected Mendelian ratios at E15.5, only 14% of mice (versus expected 25%) are obtained by P21
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cardiovascular system
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• at E.15.5, 73% of embryos exhibit superficial vessel defects
|
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• at E.15.5, 89% of embryos exhibit hypovascularization
|
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• ex vivo, aorta rings from surviving 6-week-old mice embedded in Matrigel exhibit severely reduced VEGF-mediated capillary sprouting relative to control aortic ring explants
|
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• at E.15.5, embryos display various degrees of subcutaneous hemorrhages
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integument
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• at E.15.5, embryos display various degrees of subcutaneous hemorrhages
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• at E.15.5, 77% of embryos exhibit prominent subcutaneous edema
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liver/biliary system
pale liver
(
J:253757
)
|
• at E.15.5, 65% of embryos exhibit pale liver
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nervous system
|
• at E.15.5, 89% of embryos exhibit hypovascularized, pale brain meninges
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homeostasis/metabolism
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• at E.15.5, 77% of embryos exhibit prominent subcutaneous edema
|
