Phenotypes associated with this allele

• Allele Symbol: Klhdc10^tm1Hijo
• Allele Name: targeted mutation 1, Hidenori Ichijo
• Allele ID: MGI:6343386
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klhdc10^tm1Hijo/Klhdc10^tm1Hijo	B6J.B6N-Klhdc10^tm1Hijo	MGI:6763133

Genotype
MGI:6763133

hm1

• Allelic Composition: Klhdc10^tm1Hijo/Klhdc10^tm1Hijo
• Genetic Background: B6J.B6N-Klhdc10^tm1Hijo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:251158 )

• following treatment with high doses of recombinant mouse TNF (mTNF), mice are totally protected from mTNF-induced lethality, unlike wild-type controls

immune system

decreased circulating interleukin-6 level ( J:251158 )

• at 6 hours after mTNF injection, serum concentration of IL-6 is significantly lower than that in wild-type controls

decreased interleukin-6 secretion ( J:251158 )

• at 6 hours after mTNF injection, mice exhibit significantly reduced IL-6 mRNA levels in the spleen and small intestine, but not in liver, relative to wild-type controls

decreased inflammatory response ( J:251158 )

• mice are totally resistant to mTNF-induced lethality and hypothermia, unlike wild-type controls

• however, mTNF-induced systemic necroptosis is unaffected, as determined by tissue damage markers (including ALT, LDH, and mitochondrial gene expression) in the serum at 6 hours after mTNF injection

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:251158 )

• at 6 hours after mTNF injection, serum concentration of IL-6 is significantly lower than that in wild-type controls