Analysis Tools
immune system
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• naive CD4+ T cells show a marked decrease in the extent of store-operated Ca2+ entry after TCR stimulation with anti-CD3 antibody and ionomycin and after passive store depletion with thapsigargin
• upon TCR stimulation with anti-CD3 and anti-CD28 antibodies, naive CD4+ T cells show reduced induction of NFATc1 protein production (but no change in NFATc2 protein abundance), suggesting impaired activation of the Ca2+-NFAT pathway
• upon TCR stimulation with anti-CD3 antibody, naive CD4+ T cells show a marked reduction in the % of p-JNK+ cells, indicating impaired activation of the JNK signaling pathway
• naive CD4+ T cells stimulated with anti-CD3 antibody secrete significantly less IL-2 than similarly stimulated control cells
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• naive CD4+ T cells stimulated with anti-CD3 antibody secrete significantly less IL-2 than similarly stimulated control cells
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hematopoietic system
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• naive CD4+ T cells show a marked decrease in the extent of store-operated Ca2+ entry after TCR stimulation with anti-CD3 antibody and ionomycin and after passive store depletion with thapsigargin
• upon TCR stimulation with anti-CD3 and anti-CD28 antibodies, naive CD4+ T cells show reduced induction of NFATc1 protein production (but no change in NFATc2 protein abundance), suggesting impaired activation of the Ca2+-NFAT pathway
• upon TCR stimulation with anti-CD3 antibody, naive CD4+ T cells show a marked reduction in the % of p-JNK+ cells, indicating impaired activation of the JNK signaling pathway
• naive CD4+ T cells stimulated with anti-CD3 antibody secrete significantly less IL-2 than similarly stimulated control cells
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