Analysis Tools
nervous system
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• mice exhibit upregulation of inflammation-related genes (e.g. Gh, S100a8, and S100a9) in the brain
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• at 10 weeks of age, the average diameter of axons in the corpus callosum is significantly smaller than that in wild-type controls
• the ratio of myelin with inner tongue swelling is significantly higher than that in wild-type controls
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• at 10 weeks of age, the G-ratio (inner compact myelin diameter/outer compact myelin diameter) in corpus callosum samples is significantly higher than that in wild-type controls, indicating a thinner myelin
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• mice exhibit mild hypomyelination in the corpus callosum, as shown by a subtle but significant increase in the G-ratio
• however, in vitro proliferation, differentiation, and morphology of cultured oligodendrocyte precursor cells is normal
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• mice show a significant reduction in PPI (74-dB prepulse and 110-dB trial pulse) relative to wild-type controls, suggesting the possibility of schizophrenia-like phenotypes
• however, acoustic startle response to a 110-dB test pulse is normal
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behavior/neurological
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• mice show no significant differences in wire-hanging ability, grip strength, hot plate latency or in the open-field test, Y-maze test, elevated plus maze test, fear conditioning test, and Barnes maze test relative to wild-type controls
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• mice show a tendency toward reduced anxiety-like behavior, with a relatively strong tendency to frequently transit in the light-dark transition test and to actively come in contact with other mice in the social interaction test
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immune system
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• mice exhibit upregulation of inflammation-related genes (e.g. Gh, S100a8, and S100a9) in the brain
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