Analysis Tools
renal/urinary system
kidney cyst
(
J:246596
)
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• mice develop mild renal cystic disease, with 6- and 12-month old mice showing small renal cysts
• mice administered desmopressin between 4 and 16 weeks of age show renal cysts which are not seen in wild-type mice
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• small cortical cysts are seen at 12 months of age
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• small medullary cysts are seen at 12 months of age
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• kidney to body weight ratios are higher compared to wild-type mice at 12 months of age
• mice administered desmopressin between 4 and 16 weeks of age show a greater increase in kidney to body weight ratios than controls
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• 12-month-old mice exhibit a mild urine concentration defect after 24 hours dehydration and are able to excrete a water load faster
• renal cAMP levels tend to be higher in the kidneys but not in the hearts
• mice administered desmopressin between 4 and 16 weeks of age show a greater increase in cAMP levels compared to controls
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cardiovascular system
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• mice exhibit higher left ventricle ejection fractions
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• mice exhibit higher left ventricle ejection fractions on echocardiography
• however, no difference in left ventricle mass is seen
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• mice exhibit lower aortic blood pressures
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growth/size/body
kidney cyst
(
J:246596
)
|
• mice develop mild renal cystic disease, with 6- and 12-month old mice showing small renal cysts
• mice administered desmopressin between 4 and 16 weeks of age show renal cysts which are not seen in wild-type mice
|
|
• small cortical cysts are seen at 12 months of age
|
|
• small medullary cysts are seen at 12 months of age
|
|
• kidney to body weight ratios are higher compared to wild-type mice at 12 months of age
• mice administered desmopressin between 4 and 16 weeks of age show a greater increase in kidney to body weight ratios than controls
|
homeostasis/metabolism
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• total phosphodiesterase (PDE) and phosphodiesterase 1(PDE1) activities are reduced in the kidney
• PDE3 and PDE4 activities are increased in the kidney
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muscle
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• mice exhibit higher left ventricle ejection fractions
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reproductive system
| N |
• males and females are fertile and litter sizes are normal
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