Phenotypes associated with this allele

• Allele Symbol: Pdgfd^tm1Ueks
• Allele Name: targeted mutation 1, Ulf Eriksson
• Allele ID: MGI:6343510
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdgfd^tm1Ueks/Pdgfd^tm1Ueks	B6.Cg-Pdgfd^tm1Ueks	MGI:6361865

Genotype
MGI:6361865

hm1

• Allelic Composition: Pdgfd^tm1Ueks/Pdgfd^tm1Ueks
• Genetic Background: B6.Cg-Pdgfd^tm1Ueks

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased litter size ( J:249014 )

• first generation mice derived from homozygous breeding pairs are born at a lower average number per litter relative to wild-type controls

• however, mice derived from heterozygous crossings are born in normal Mendelian ratios and generally heathy up to 18 months of age

growth/size/body

increased body weight ( J:249014 )

• surviving mice are significantly heavier than wild-type controls during the first 3 weeks and throughout the 16-week period of observation

cardiovascular system

cardiovascular system phenotype ( J:249014 )

N • adult hearts are morphologically normal with a normal vascular network and no significant changes in wet and dry heart weights relative to wild-type controls

abnormal pericyte morphology ( J:249014 )

• detached pericytes with rough body morphology and thick processes connecting to vessels are observed in cardiac vasculature; pericyte processes appear less organized and shorter and vascular coverage by NG2-expressing pericytes is significantly lower than that in wild-type hearts

• however, no vascular leakage is detected

increased systemic arterial diastolic blood pressure ( J:249014 )

• at 17-18 weeks of age, males show a slight but significant elevation (+10.6%) in diastolic blood pressure relative to age-matched wild-type controls

increased systemic arterial systolic blood pressure ( J:249014 )

• at 17-18 weeks of age, males show a slight but significant elevation (+5.2%) in systolic blood pressure relative to age-matched wild-type controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:249014 )

N • adult mice show normal glucose homeostasis, as determined by glucose and insulin tolerance tests

increased circulating calcium level ( J:249014 )

♂ • males, but not females, show a modest increase in serum Ca²⁺ concentrations relative to wild-type controls

decreased circulating chloride level ( J:249014 )

♂ • males, but not females, show a modest decrease in serum Cl^- concentrations relative to wild-type controls

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:249014 )

N • at 18 weeks of age, pancreas morphology is normal with no alterations in vascular density or pericyte coverage found in endocrine or exocrine tissue; a trend towards smaller pancreatic islets is observed but does not reach statistical significance