Analysis Tools
cardiovascular system
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• no significant alterations in heart size, cardiac tissue morphology or cardiac function at 12 weeks of age under baseline conditions
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• improved cardiac function with higher fractional shortening and ejection fraction values relative to wild-type controls at day 21 post MI
• enhanced functional recovery due to preservation of both diastolic and systolic left ventricular internal diameters with lower overall values than control mice at day 21 post MI
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• attenuated induction levels of genes encoding endothelial cell-specific adhesion membrane proteins, Sele and Vcam1, at day 2 post MI, with no significant changes in the induction of proinflammatory cytokines
• decreased numbers of CD45+, Ly6C+ (intermediate and high expression levels) and F4/80+ cells in cardiac tissue at day 5 post MI
• reduced induction levels of Tgfbeta1 and Il10 in the heart post MI
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immune system
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• reduced induction levels of Il10 in the heart at day 2 post MI
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• reduced magnitude of the inflammatory response after myocardial infarction (MI) by permanent ligation of the left anterior descending coronary artery
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homeostasis/metabolism
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• attenuated induction levels of genes encoding endothelial cell-specific adhesion membrane proteins, Sele and Vcam1, at day 2 post MI, with no significant changes in the induction of proinflammatory cytokines
• decreased numbers of CD45+, Ly6C+ (intermediate and high expression levels) and F4/80+ cells in cardiac tissue at day 5 post MI
• reduced induction levels of Tgfbeta1 and Il10 in the heart post MI
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• reduced induction levels of Tgfbeta1 in the heart at day 7 post MI
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muscle
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• improved cardiac function with higher fractional shortening and ejection fraction values relative to wild-type controls at day 21 post MI
• enhanced functional recovery due to preservation of both diastolic and systolic left ventricular internal diameters with lower overall values than control mice at day 21 post MI
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