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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Vgll2tm1Tm
targeted mutation 1, Takayuki Morisaki
MGI:6343554
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Vgll2tm1Tm/Vgll2tm1Tm involves: 129S2/SvPas * C57BL/6J MGI:6357992


Genotype
MGI:6357992
hm1
Allelic
Composition
Vgll2tm1Tm/Vgll2tm1Tm
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vgll2tm1Tm mutation (0 available); any Vgll2 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• homozygous mice were able to run on a treadmill for a significantly shorter time and distance than controls

muscle
• in soleus muscle, both type I and type IIa fibers were reduced, and an obvious increase in type IIb fibers was detected in homozygous mice
• in extensor digitorum longus (EDL) muscle, myosin electrophoretogram showed that fast type IIa and IIx myosin were predominantly replaced by the fastest type IIb myosin

homeostasis/metabolism
• homozygous mice were able to run on a treadmill for a significantly shorter time and distance than controls





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory