behavior/neurological
• homozygous mice were able to run on a treadmill for a significantly shorter time and distance than controls
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muscle
• in soleus muscle, both type I and type IIa fibers were reduced, and an obvious increase in type IIb fibers was detected in homozygous mice
• in extensor digitorum longus (EDL) muscle, myosin electrophoretogram showed that fast type IIa and IIx myosin were predominantly replaced by the fastest type IIb myosin
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homeostasis/metabolism
• homozygous mice were able to run on a treadmill for a significantly shorter time and distance than controls
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