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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Stx3Gt(EUCE320f12)1.2Hmgu
gene trap EUCE320f12, derivative 1.2, Helmholtz Zentrum Muenchen GmbH
MGI:6355364
Summary 2 genotypes


Genotype
MGI:7469800
hm1
Allelic
Composition
Stx3Gt(EUCE320f12)1.2Hmgu/Stx3Gt(EUCE320f12)1.2Hmgu
Genetic
Background
B6.129P2(Cg)-Stx3Gt(EUCE320f12)1.2Hmgu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stx3Gt(EUCE320f12)1.2Hmgu mutation (0 available); any Stx3 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• heterozygous intercrosses fail to produce homozygotes; reported as embryonic lethal but stage of lethality is not specified




Genotype
MGI:7469801
ht2
Allelic
Composition
Stx3Gt(EUCE320f12)1.2Hmgu/Stx3+
Genetic
Background
B6.129P2(Cg)-Stx3Gt(EUCE320f12)1.2Hmgu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stx3Gt(EUCE320f12)1.2Hmgu mutation (0 available); any Stx3 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• in a model of passive systemic anaphylaxis, mice sensitized i.p. with anti-DNP IgE and challenged i.p. with DNP-HAS exhibit a normal hypothermic response at 50 min post-challenge
• plasma membrane capacitance (Cm) recordings of single peritoneal mast cells (MCs) after stimulation by intracellular dialysis of GTPgammaS and Ca2+ show that MCs achieve the same total increase in plasma membrane area (deltaCm) at a significantly lower rate than wild-type MCs; however, time between cell access and beginning of the exocytic burst is normal
• after stimulation with PMA/ionomycin, peritoneal MCs show a significant reduction in intracellular multigranular compartments, indicating a partial defect in compound exocytosis

hematopoietic system
• plasma membrane capacitance (Cm) recordings of single peritoneal mast cells (MCs) after stimulation by intracellular dialysis of GTPgammaS and Ca2+ show that MCs achieve the same total increase in plasma membrane area (deltaCm) at a significantly lower rate than wild-type MCs; however, time between cell access and beginning of the exocytic burst is normal
• after stimulation with PMA/ionomycin, peritoneal MCs show a significant reduction in intracellular multigranular compartments, indicating a partial defect in compound exocytosis

mortality/aging
N
• mice are viable, grossly normal, and exhibit a normal life span when raised in a specific pathogen-free facility

cellular
• plasma membrane capacitance (Cm) recordings of single peritoneal mast cells (MCs) after stimulation by intracellular dialysis of GTPgammaS and Ca2+ show that MCs achieve the same total increase in plasma membrane area (deltaCm) at a significantly lower rate than wild-type MCs; however, time between cell access and beginning of the exocytic burst is normal
• after stimulation with PMA/ionomycin, peritoneal MCs show a significant reduction in intracellular multigranular compartments, indicating a partial defect in compound exocytosis





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory