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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stx4atm1.1Radac
targeted mutation 1.1, Roberto Adachi
MGI:6355365
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stx4atm1.1Radac/Stx4atm1.1Radac involves: 129S4/SvJaeSor * C57BL/6J MGI:7469797
cn2
 		Stx4atm1.1Radac/Stx4atm1.1Radac
Tg(Cma1-cre)ARoer/0 		involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6J MGI:7469807


Genotype
MGI:7469797
hm1
Allelic
Composition		 Stx4atm1.1Radac/Stx4atm1.1Radac
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stx4atm1.1Radac mutation (0 available); any Stx4a mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:275367 )
N
• mice are viable and grossly normal and exhibit a normal life span when raised in a specific pathogen-free facility

immune system
immune system phenotype ( J:275367 )
N
• plasma membrane capacitance (Cm) recordings of single peritoneal mast cells (MCs) after stimulation by intracellular dialysis of GTPgammaS and Ca2+ show no differences in the magnitude or speed of exocytosis relative to wild-type MCs
• no significant differences in the total number, distribution or structure of MCs are observed




Genotype
MGI:7469807
cn2
Allelic
Composition		 Stx4atm1.1Radac/Stx4atm1.1Radac
Tg(Cma1-cre)ARoer/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stx4atm1.1Radac mutation (0 available); any Stx4a mutation (22 available)
Tg(Cma1-cre)ARoer mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:275367 )
N
• mice are viable, grossly normal, and exhibit a normal life span when raised in a specific pathogen-free facility

immune system
immune system phenotype ( J:275367 )
N
• plasma membrane capacitance (Cm) recordings of single peritoneal mast cells (MCs) after stimulation by intracellular dialysis of GTPgammaS and Ca2+ show no differences in the magnitude or speed of exocytosis relative to control MCs; time between cell access and beginning of the exocytic burst and frequency distribution of (Cm) step sizes between 1 and 15% of total (deltaCm) are normal
• after stimulation with PMA/ionomycin, peritoneal MCs show normal exocytosis-related ultrastructural changes relative to control MCs
• mice exhibit normal secretion of MC mediators, independent of the mediator measured or the stimuli employed
• no significant differences in the total number, distribution or structure of MCs are observed




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory