Phenotypes associated with this allele

• Allele Symbol: Rbmxl2^tm1.2Dell
• Allele Name: targeted mutation 1.2, David J Elliott
• Allele ID: MGI:6355368
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rbmxl2^tm1.2Dell/Rbmxl2^tm1.2Dell	involves: 129 * BALB/c * C57BL/6 * SJL	MGI:6367658

Genotype
MGI:6367658

hm1

• Allelic Composition: Rbmxl2^tm1.2Dell/Rbmxl2^tm1.2Dell
• Genetic Background: involves: 129 * BALB/c * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:275203 )

♀N • female mice exhibit normal fertility

azoospermia ( J:275203 )

♂

abnormal spermatid morphology ( J:275203 )

♂ • only few round spermatids and no elongated spermatids are observed

arrest of male meiosis ( J:275203 )

♂ • during the diplotene substage of meiotic prophase with few escaping cells

♂ • however, germ cells exhibit normal synaptonemal complex formation and meiotic homology searching

increased male germ cell apoptosis ( J:275203 )

♂

small testis ( J:275203 )

♂

male infertility ( J:275203 )

♂

cellular

azoospermia ( J:275203 )

♂

abnormal spermatid morphology ( J:275203 )

♂ • only few round spermatids and no elongated spermatids are observed

abnormal cell physiology ( J:275203 )

♂ • male germ cells exhibit increased mis-splicing during meiosis compared with wild-type cells

arrest of male meiosis ( J:275203 )

♂ • during the diplotene substage of meiotic prophase with few escaping cells

♂ • however, germ cells exhibit normal synaptonemal complex formation and meiotic homology searching

increased male germ cell apoptosis ( J:275203 )

♂

endocrine/exocrine glands

small testis ( J:275203 )

♂