Phenotypes associated with this allele

• Allele Symbol: Dlk2^tm1.1Geno
• Allele Name: targeted mutation 1.1, Genoway
• Allele ID: MGI:6355376
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dlk2^tm1.1Geno/Dlk2^tm1.1Geno	involves: 129P2/OlaHsd * C57BL/6J	MGI:6467236

Genotype
MGI:6467236

hm1

• Allelic Composition: Dlk2^tm1.1Geno/Dlk2^tm1.1Geno
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:272796 )

N • mice exhibit normal spontaneous motor activity in the open field test, with no differences in distance travelled or mean speed relative to wild-type controls

impaired behavioral response to xenobiotic ( J:272796 )

• mice are insensitive to the anxiolytic effect of alprazolam (APZ, a classical benzodiazepine) in the light-dark box (LDB) test; APZ administration fails to increase the time spent in the light box, unlike in APZ-treated wild-type controls

increased depression-related behavior ( J:272796 )

• in the novelty suppressed feeding (NSF) test, mice exhibit an increased latency to feed and a reduced amount of food intake relative to wild-type controls, suggesting increased depressive-like behavior

increased anxiety-related response ( J:272796 )

• in the light-dark box (LDB) test, mice spend significantly less time in the light box than wild-type controls

• in the elevated plus maze (EPM) test, mice spend significantly less time in the open arms than wild-type controls

• however, the number of transitions is normal in both the LDB and EPM tests

nervous system

abnormal nervous system physiology ( J:272796 )

• gene expression analysis suggests altered vulnerability to restraint stress-induced changes in the HPA-axis, the NOTCH signaling pathway and the GABAergic system