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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tmem98em1Jkn
endonuclease-mediated mutation 1, Ian J Jackson
MGI:6355418
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tmem98em1Jkn/Tmem98em1Jkn C57BL/6J-Tmem98em1Jkn MGI:6358116
ht2
 		Tmem98em1Jkn/Tmem98+ C57BL/6J-Tmem98em1Jkn MGI:6358115
ht3
 		Tmem98em1Jkn/Tmem98em2Jkn C57BL/6J-Tmem98em1Jkn MGI:6358120
ht4
 		Tmem98em1Jkn/Tmem98Rwhs involves: BALB/cAnN * C3H/HeN * C57BL/6J MGI:6358122
ht5
 		Tmem98em1Jkn/Tmem98tm1b(EUCOMM)Wtsi involves: C57BL/6J * C57BL/6N MGI:6358123


Genotype
MGI:6358116
hm1
Allelic
Composition		 Tmem98em1Jkn/Tmem98em1Jkn
Genetic
Background		 C57BL/6J-Tmem98em1Jkn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem98em1Jkn mutation (0 available); any Tmem98 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryo phenotype ( J:277123 )
N
• pups born at expected Mendelian ratio

mortality/aging
mortality/aging ( J:277123 )
N
• viable

pigmentation
abnormal iris pigmentation ( J:277123 )
• progressive appearance of white spots from age 3 months

vision/eye
vision/eye phenotype ( J:277123 )
N
• normal a-wave and b-wave amplitudes
• normal eye axial length
abnormal iris pigmentation ( J:277123 )
• progressive appearance of white spots from age 3 months
abnormal retina outer nuclear layer morphology ( J:277123 )
• folds in outer nuclear layer from age 3 months




Genotype
MGI:6358115
ht2
Allelic
Composition		 Tmem98em1Jkn/Tmem98+
Genetic
Background		 C57BL/6J-Tmem98em1Jkn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem98em1Jkn mutation (0 available); any Tmem98 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryo phenotype ( J:277123 )
N
• pups born at expected Mendelian ratio

mortality/aging
mortality/aging ( J:277123 )
N
• viable

reproductive system

vision/eye
vision/eye phenotype ( J:277123 )
N
• no gross eye or retinal defects at age 5-9 months




Genotype
MGI:6358120
ht3
Allelic
Composition		 Tmem98em1Jkn/Tmem98em2Jkn
Genetic
Background		 C57BL/6J-Tmem98em1Jkn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem98em1Jkn mutation (0 available); any Tmem98 mutation (25 available)
Tmem98em2Jkn mutation (0 available); any Tmem98 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal iris pigmentation ( J:277123 )
• progressive appearance of white spots

vision/eye
abnormal iris pigmentation ( J:277123 )
• progressive appearance of white spots
abnormal retina outer nuclear layer morphology ( J:277123 )
• folds in outer nuclear layer




Genotype
MGI:6358122
ht4
Allelic
Composition		 Tmem98em1Jkn/Tmem98Rwhs
Genetic
Background		 involves: BALB/cAnN * C3H/HeN * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem98em1Jkn mutation (0 available); any Tmem98 mutation (25 available)
Tmem98Rwhs mutation (2 available); any Tmem98 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal iris pigmentation ( J:277123 )
• progressive appearance of white spots

vision/eye
abnormal iris pigmentation ( J:277123 )
• progressive appearance of white spots
abnormal retina outer nuclear layer morphology ( J:277123 )
• folds in outer nuclear layer




Genotype
MGI:6358123
ht5
Allelic
Composition		 Tmem98em1Jkn/Tmem98tm1b(EUCOMM)Wtsi
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem98em1Jkn mutation (0 available); any Tmem98 mutation (25 available)
Tmem98tm1b(EUCOMM)Wtsi mutation (0 available); any Tmem98 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:277123 )
N
• viable

vision/eye
vision/eye phenotype ( J:277123 )
N
• normal retinal pigmentation, except three faint retinal white spots in 1 of 17 mice at age 1 year




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory