About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tmem98em1Jkn
endonuclease-mediated mutation 1, Ian J Jackson
MGI:6355418
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tmem98em1Jkn/Tmem98em1Jkn C57BL/6J-Tmem98em1Jkn MGI:6358116
ht2
Tmem98em1Jkn/Tmem98+ C57BL/6J-Tmem98em1Jkn MGI:6358115
ht3
Tmem98em1Jkn/Tmem98em2Jkn C57BL/6J-Tmem98em1Jkn MGI:6358120
ht4
Tmem98em1Jkn/Tmem98Rwhs involves: BALB/cAnN * C3H/HeN * C57BL/6J MGI:6358122
ht5
Tmem98em1Jkn/Tmem98tm1b(EUCOMM)Wtsi involves: C57BL/6J * C57BL/6N MGI:6358123


Genotype
MGI:6358116
hm1
Allelic
Composition
Tmem98em1Jkn/Tmem98em1Jkn
Genetic
Background
C57BL/6J-Tmem98em1Jkn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem98em1Jkn mutation (0 available); any Tmem98 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
N
• pups born at expected Mendelian ratio

mortality/aging
N
• viable

pigmentation
• progressive appearance of white spots from age 3 months

vision/eye
N
• normal a-wave and b-wave amplitudes
• normal eye axial length
• progressive appearance of white spots from age 3 months
• folds in outer nuclear layer from age 3 months




Genotype
MGI:6358115
ht2
Allelic
Composition
Tmem98em1Jkn/Tmem98+
Genetic
Background
C57BL/6J-Tmem98em1Jkn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem98em1Jkn mutation (0 available); any Tmem98 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
N
• pups born at expected Mendelian ratio

mortality/aging
N
• viable

reproductive system

vision/eye
N
• no gross eye or retinal defects at age 5-9 months




Genotype
MGI:6358120
ht3
Allelic
Composition
Tmem98em1Jkn/Tmem98em2Jkn
Genetic
Background
C57BL/6J-Tmem98em1Jkn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem98em1Jkn mutation (0 available); any Tmem98 mutation (25 available)
Tmem98em2Jkn mutation (0 available); any Tmem98 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• progressive appearance of white spots

vision/eye
• progressive appearance of white spots
• folds in outer nuclear layer




Genotype
MGI:6358122
ht4
Allelic
Composition
Tmem98em1Jkn/Tmem98Rwhs
Genetic
Background
involves: BALB/cAnN * C3H/HeN * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem98em1Jkn mutation (0 available); any Tmem98 mutation (25 available)
Tmem98Rwhs mutation (2 available); any Tmem98 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• progressive appearance of white spots

vision/eye
• progressive appearance of white spots
• folds in outer nuclear layer




Genotype
MGI:6358123
ht5
Allelic
Composition
Tmem98em1Jkn/Tmem98tm1b(EUCOMM)Wtsi
Genetic
Background
involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem98em1Jkn mutation (0 available); any Tmem98 mutation (25 available)
Tmem98tm1b(EUCOMM)Wtsi mutation (0 available); any Tmem98 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• viable

vision/eye
N
• normal retinal pigmentation, except three faint retinal white spots in 1 of 17 mice at age 1 year





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory