Phenotypes associated with this allele

• Allele Symbol: Tardbp^Rgsc2223
• Allele Name: Riken Genomic Sciences Center 2223
• Allele ID: MGI:6355456
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tardbp^Rgsc2223/Tardbp^Rgsc2223	C57BL/6J-Tardbp^Rgsc2223	MGI:6400961
hm2	Tardbp^Rgsc2223/Tardbp^Rgsc2223	involves: C57BL/6JJcl * DBA/2J	MGI:6400959
ht3	Tardbp^Rgsc2223/Tardbp^Rgsc2268	involves: C57BL/6JJcl * DBA/2J	MGI:6400965

Genotype
MGI:6400961

hm1

• Allelic Composition: Tardbp^Rgsc2223/Tardbp^Rgsc2223
• Genetic Background: C57BL/6J-Tardbp^Rgsc2223

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:265666 )

Genotype
MGI:6400959

hm2

• Allelic Composition: Tardbp^Rgsc2223/Tardbp^Rgsc2223
• Genetic Background: involves: C57BL/6JJcl * DBA/2J

behavior/neurological

decreased grip strength ( J:265666 )

• 38% reduction in tetanic strength in tibialis anterior muscles at age 24 month

• progressive grip strength deficit from age 12 months

mortality/aging

mortality/aging ( J:265666 )

N • viable

nervous system

decreased motor neuron number ( J:265666 )

• 28% reduction in sciatic MNs at L4-L5 at age 24 months

• 15% reduction in motor units innervating extensor digitorum (EDL) muscle at age 24 months

Genotype
MGI:6400965

ht3

• Allelic Composition: Tardbp^Rgsc2223/Tardbp^Rgsc2268
• Genetic Background: involves: C57BL/6JJcl * DBA/2J

mortality/aging

prenatal lethality, incomplete penetrance ( J:265666 )

• fewer than expected mice are born