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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		OtpM1H
mutation 1, Harwell
MGI:6355465
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		OtpM1H/OtpM1H C3H.Cg-OtpM1H MGI:6402815
ht2
 		OtpM1H/Otp+ C3H.Cg-OtpM1H MGI:6402817
ht3
 		OtpM1H/Otptm1Asim involves: 129P2/OlaHsd * C3H/HeH * C57BL/6J MGI:6402821


Genotype
MGI:6402815
hm1
Allelic
Composition		 OtpM1H/OtpM1H
Genetic
Background		 C3H.Cg-OtpM1H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
OtpM1H mutation (0 available); any Otp mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:6402817
ht2
Allelic
Composition		 OtpM1H/Otp+
Genetic
Background		 C3H.Cg-OtpM1H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
OtpM1H mutation (0 available); any Otp mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
increased body fat mass ( J:251771 )
• from age 6 weeks on regular chow
abnormal fat pad morphology ( J:251771 )
• increased fat depot weight on regular chow

behavior/neurological
increased food intake ( J:251771 )
• from age 5 to 15 weeks on regular chow

growth/size/body
increased body fat mass ( J:251771 )
• from age 6 weeks on regular chow
increased lean body mass ( J:251771 )
• at age 10 and 12 weeks on regular chow
decreased body weight ( J:251771 )
• lower body weight at age 3 weeks on regular chow
obese ( J:251771 , J:251771 )
• significantly heavier from age 7 weeks on regular chow when measured weekly (J:251771)
• significantly heavier from age 8 weeks on regular chow when measured fortnightly (J:251771)
• significantly heavier from age 6 weeks on regular chow when measured fortnightly (J:251771)
increased body length ( J:251771 )
• on regular chow

homeostasis/metabolism
increased circulating insulin level ( J:251771 )
• at age 8 and 12 weeks on regular chow after 4-6h fast
increased circulating leptin level ( J:251771 )
• at age 8 and 12 weeks on regular chow after 4-6h fast
abnormal energy homeostasis ( J:251771 , J:251771 )
• overall positive energy balance between age 5 and 10 weeks on regular chow (J:251771)
• significant increase in energy extracted from food at age 11 weeks on regular chow (J:251771)
• increase in metabolizable energy intake (MEI) between age 7 and 14 weeks on regular chow (J:251771)
increased energy expenditure ( J:251771 )
• from age 6 weeks on regular chow
• at age 5 weeks on regular chow
impaired glucose tolerance ( J:251771 )
• at age 12 weeks on regular chow after 5-6h fast
insulin resistance ( J:251771 )
• at age 12 weeks on regular chow after 5-6h fast

skeleton
decreased bone mineral density ( J:251771 )
• on regular chow




Genotype
MGI:6402821
ht3
Allelic
Composition		 OtpM1H/Otptm1Asim
Genetic
Background		 involves: 129P2/OlaHsd * C3H/HeH * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
OtpM1H mutation (0 available); any Otp mutation (17 available)
Otptm1Asim mutation (1 available); any Otp mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory