Phenotypes associated with this allele

• Allele Symbol: Tafa2^tm1Zgwg
• Allele Name: targeted mutation 1, Zhugang Wang
• Allele ID: MGI:6355950
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tafa2^tm1Zgwg/Tafa2^tm1Zgwg	involves: C57BL/6	MGI:6360861

Genotype
MGI:6360861

hm1

• Allelic Composition: Tafa2^tm1Zgwg/Tafa2^tm1Zgwg
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired long-term object recognition memory ( J:271697 )

• in the choice phase of the novel object recognition test performed at 24 hours, mice show a decrease in the exploratory preference for novel objects, indicating impaired long-term memory in novel object recognition

impaired short-term object recognition memory ( J:271697 )

• in the choice phase of the novel object recognition test performed at 1 hour, mice show a decrease in the exploratory preference for novel objects, indicating impaired short-term memory in novel object recognition

impaired spatial learning ( J:271697 )

• mice show a longer latency to find the hidden platform during the train period of the Morris water maze, indicating impaired spatial learning

abnormal spatial reference memory ( J:271697 )

• mice spend less time in the target quadrant and fewer number of times crossing the original platform position during the Morris water maze, indicating impaired spatial memory

increased coping response ( J:271697 )

• mice spend less immotile time in the forced swim test and tail-suspension test indicating decreased depression-like behavior

increased anxiety-related response ( J:271697 )

• mice spend less time in the central zone of the open-field, show reduced open-arm exploration and increased number of entries to the closed arms in the elevated plus maze test indicating increase in anxiety-like behavior

nervous system

increased brain apoptosis ( J:271697 )

• apoptosis is elevated in the cerebral cortex and hippocampus

loss of hippocampal neurons ( J:271697 )

• loss of Nissl+ neurons in the hippocampus

loss of cortex neurons ( J:271697 )

• loss of Nissl+ neurons in the cerebral cortex

• however, no gross changes in brain organization or connectivity are seen

abnormal dendrite morphology ( J:271697 )

• marker analysis indicates defects in dendritic morphology in the brain

abnormal synapse morphology ( J:271697 )

• marker analysis indicates defects in synaptic morphology in the brain

cellular

increased brain apoptosis ( J:271697 )

• apoptosis is elevated in the cerebral cortex and hippocampus

increased cellular glucose import ( J:271697 )

• global uptake of glucose in the brain is increased