About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Camsap2tm1Ltm
targeted mutation 1, Masatoshi Takeichi
MGI:6355951
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Camsap2tm1Ltm/Camsap2tm1Ltm Not Specified MGI:6721051
cx2
 		Camsap2tm1Ltm/Camsap2tm1Ltm
Camsap3tm1.1Ltm/Camsap3tm1.1Ltm 		involves: C57BL/6N * FVB/N MGI:6721054


Genotype
MGI:6721051
hm1
Allelic
Composition		 Camsap2tm1Ltm/Camsap2tm1Ltm
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Camsap2tm1Ltm mutation (0 available); any Camsap2 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:265916 )
• at P43, mice are significantly smaller than wild-type controls
postnatal growth retardation ( J:265916 )
• both sexes show postnatal growth retardation after P15
• however, mice are born with no gross developmental defects

nervous system
decreased brain size ( J:265916 )
• at P25, brains are smaller than those of wild-type controls
• however, brain structures including the hippocampus appear grossly normal
abnormal dendrite morphology ( J:265916 )
• in vitro, cultured hippocampal neurons from E16.5 embryos exhibit a reduced number of secondary branches in their dendrites at day 6 (DIV6)
• however, hippocampal neurons develop a single axon and multiple dendrites, similar to wild-type neurons




Genotype
MGI:6721054
cx2
Allelic
Composition		 Camsap2tm1Ltm/Camsap2tm1Ltm
Camsap3tm1.1Ltm/Camsap3tm1.1Ltm
Genetic
Background		 involves: C57BL/6N * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Camsap2tm1Ltm mutation (0 available); any Camsap2 mutation (66 available)
Camsap3tm1.1Ltm mutation (0 available); any Camsap3 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:265916 )
• in vitro, cultured hippocampal neurons from double mutant embryos exhibit enhanced multiple axon formation at DIV6, similar to homozygous Camsap3tm1.1Ltm neurons, indicating neuron polarity defects
abnormal dendrite morphology ( J:265916 )
• in vitro, cultured hippocampal neurons from double mutant embryos exhibit a reduced number of secondary branches in their dendrites at DIV6, similar to homozygous Camsap3tm1.1Ltm neurons
abnormal neuron polarity ( J:265916 )
• in vitro, cultured hippocampal neurons from double mutant embryos exhibit enhanced multiple axon formation at DIV6, similar to homozygous Camsap3tm1.1Ltm neurons, indicating neuron polarity defects




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory