Phenotypes associated with this allele

• Allele Symbol: Nr5a1^em1Kemi
• Allele Name: endonuclease-mediated mutation 1, Kenji Miyado
• Allele ID: MGI:6355954
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr5a1^em1Kemi/Nr5a1^em1Kemi	involves: C57BL/6 * DBA/2	MGI:6368873
ht2	Nr5a1^em1Kemi/Nr5a1^+	involves: C57BL/6 * DBA/2	MGI:6368884

Genotype
MGI:6368873

hm1

• Allelic Composition: Nr5a1^em1Kemi/Nr5a1^em1Kemi
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

absent adrenal gland ( J:277036 )

• at age E18.5

abnormal testis morphology ( J:277036 )

♂ • testicular cords absent in E13.5 and E18.5 embryos

mortality/aging

postnatal lethality, complete penetrance ( J:277036 )

• newborn mice die within 1 week after birth

reproductive system

reproductive system phenotype ( J:277036 )

♀N • normal gonadal morphology in females

abnormal testis morphology ( J:277036 )

♂ • testicular cords absent in E13.5 and E18.5 embryos

small gonad ( J:277036 , J:277036 )

♀ • normal to slightly reduced gonad size in females at age E18.5 (J:277036)

♂ • hypoplastic female-type gonads in the intra-abdominal region in males at age E18.5 (J:277036)

secondary sex reversal ( J:277036 )

♂ • female-type external genitalia in males at age E18.5

Genotype
MGI:6368884

ht2

• Allelic Composition: Nr5a1^em1Kemi/Nr5a1⁺
• Genetic Background: involves: C57BL/6 * DBA/2

endocrine/exocrine glands

small adrenal glands ( J:277036 )

• slightly smaller at age 8 weeks

small testis ( J:277036 )

♂ • slightly smaller at age 8 weeks

mortality/aging

mortality/aging ( J:277036 )

N • healthy

reproductive system

reproductive system phenotype ( J:277036 )

N • normal gonadal morphology

N • fertile

small testis ( J:277036 )

♂ • slightly smaller at age 8 weeks