Phenotypes associated with this allele

• Allele Symbol: Arc^em1Pfw
• Allele Name: endonuclease-mediated mutation 1, Paul Worley
• Allele ID: MGI:6356322
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arc^em1Pfw/Arc^em1Pfw	involves: C57BL/6J	MGI:6393443

Genotype
MGI:6393443

hm1

• Allelic Composition: Arc^em1Pfw/Arc^em1Pfw
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:276388 )

N • normal behavior in plus maze and open field tests

impaired contextual conditioning behavior ( J:276388 )

• no consistent freezing in response to conditioned stimulus (CS) presented in a new context

impaired cued conditioning behavior ( J:276388 )

• development of freezing response during inter-trial intervals (ITIs) in delayed fear conditioning test (auditory cue (conditioned stimulus (CS)) with foot shock (unconditioned stimulus (US)))

• low acquisition of freezing response to the CS in delayed fear conditioning test

• lower levels of freezing in response to CS after 24h delay in delayed fear conditioning test

• normal levels of motor activation and body displacement in reaction to the UC in delayed fear conditioning test

abnormal spatial reference memory ( J:276388 )

• marginal memory deficiency in Morris water maze test